Workpackage 3: Project IP7

Title of the project: Influence of antibiotic resistant staphylococcal species on persistence and dissemination of LA-MRSA

Contact IP7

PD Dr. med Wilma Ziebuhr
University of Würzburg
Institute for Molecular Infection Biology
Josef-Schneider-Str. 2 / Blg. D15
D-97080 Würzburg

Phone +49 931-31-82154
Fax +49 931-31-82578
E-mail: w.ziebuhr[at]mail.uni-wuerzburg.de

Description

In the proposed research we hypothesise that LA-MRSA can acquire antimicrobial resistance from other S. aureus and Coagulase-negative staphylococci (CoNS) or vice versa in the same ecological niche, and that this may also be the case in LA-MRSA belonging to other than the ST398 clonal lineage. In addition we will analyse whether LA-MRSA and CoNS mutually support their persistence in the environment, and that biofilm formation and quorum-sensing interactions as well as subinhibitory antibiotic concentrations may play a significant role in this process.